Significance of Tumor–Stroma Ratio (TSR) in Predicting Outcomes of Malignant Tumors

Background and Objectives: The present study aimed to elucidate the distribution prognostic implications of tumor–stroma ratio (TSR) in various malignant tumors through a meta-analysis. Materials Methods: This meta-analysis included 51 eligible studies with information for overall survival (OS) or disease-free (DFS), according TSR. In addition, subgroup analysis was performed based on criteria high Results: estimated rate TSR 0.605 (95% confidence interval (CI) 0.565–0.644) tumors. rates ranged from 0.276 0.865. highest found endometrial cancer (0.865, 95% CI 0.827–0.895). colorectal, esophageal, stomach cancers were 0.622, 0.529, 0.448, respectively. cases, patients had better OS DFS than those low (hazard (HR) 0.631, 0.542–0.734, HR 0.564, 0.0.476–0.669, respectively). Significant correlations breast, cervical, esophagus, head neck, ovary, stomach, urinary tract cancers. there significant larynx, lung, cancers, significantly correlated worse DFS. Conclusions: different can be useful predicting prognosis routine microscopic examination